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Analytical and Bioanalytical Techniques

March 4, 2013

Introduction:

A sub-discipline of analytical chemistry, Bioanalysis covers the quantitative measurement of xenobiotics and biotics in a biological system. xenobiotics means drugs and their metabolites, and biological molecules in unnatural locations/concentrations. biotics are macromolecules, proteins, DNA, large molecule drugs and metabolites.

An image displaying the bioanalytical imageAlmost all scientific endeavors are dependent upon accurate quantification of drugs and endogenous substances in biological samples; the focus of bioanalysis in the pharmaceutical industry is to provide a quantitative measure of the active drug and/or its metabolite(s) for the purpose of pharmacokinetics, toxicokinetics, bioequivalence and exposure–response. Bioanalysis also applies to drugs used for illicit purposes, forensic investigations, anti-doping testing in sports, and environmental concerns.

Bioanalysis was traditionally thought of in terms of measuring small molecule drugs. However, the past twenty years has seen an increase in biopharmaceuticals (e.g. necessary protein and peptides), which have been developed to address many of the same to deal with many of the same illnesses as little molecules. These bigger biomolecules have offered their own exclusive complications to quantification.

The first studies measuring drugs in biological fluids were carried out to determine possible overdosing as part of the new science of forensic medicine, which is known as toxicology.

Initially, nonspecific assays were used to determining drugs in medical fluids. These were unable to discriminate between the drug and its metabolites; for example, aspirin (circa 1900) and sulfonamides (developed in the 1930s) were quantified by the use of colorimetric assays. Antibiotics were quantified by their ability to inhibit bacterial growth. The 1930s also saw the rise of pharmacokinetics, and as such the desire for more specific assays.

Modern drugs are more potent, which has required more sensitive bioanalytical assays to accurately and reliably determine these drugs at lower concentrations. This has driven improvements in technology and analytical methods.

OMICS Publishing Group is an open access scientific journal publisher which publishes articles in about 200 open access scientific journals. This group is now organizing the 3rd International Conference and Exhibition on Analytical and Bioanalytical Techniques at Las Vegas, USA on October 15-17, 2013.

OMICS Groups Analytical and Bioanalytical Techniques 2013 aims to provide a complete source of authentic information about the current developments in the field of analytical chemistry.

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